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Divalproex sodium is a stable co-ordination compound comprised of sodium valproate and valproic acid in a 1:1 molar relationship and formed during the partial neutralization of valproic acid with 0. 20 mg of valproate semisodium* per tablet (equivalent to 500 mg of valproic acid). Depakote tablets come in 3 strengths: 125 mg; 250 mg; 500 mg; Depakote ER: Depakote ER is intended for once-a-day oral administration. ★ Cost Of Depakote Per Pill how much does depakote cost. 69 - $2. The recommended starting dose is 250 mg twice daily. An extended release version, Depakote ER, is a little better than regular Depakote How Much Per Pill divalproex, but not enough to justify the cost in most cases; This medication was originally developed as an anti-seizure medication Divalproex ER (Depakote ER) is an expensive drug used to prevent seizures caused by some forms of epilepsy This is a combination of sodium valproate and valproic acid. 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